Patents

2022

-Național patent application submitted:

Title: „Reporter cell line for testing the activity of IL-1β synthesis and secretion modulators"- Marioara Chiritoiu-Butnaru1, Gabriela Chiritoiu1, Simona Ghenea1, Gheorghita Isvoranu2,

1. Institute of Biochemistry of the Romanian Academy, Bucharest, Romania

2. "Victor Babeș" National Institute of Pathology, Bucharest, Romania

Publications

2021

1. "Therapeutic potential of interleukin-15 in cancer (Review)" Gheorghita Isvoranu, Mihaela Surcel, Adriana Narcisa Munteanu, Ovidiu Gabriel Bratu, Florentina Ionita-Radu, Monica Teodora Neagu, Marioara Chiritoiu-Butnaru, Experimental and Therapeutic Medicine, 2021 Jul;22(1):675 doi: 10.3892/etm.2021.10107. Epub 2021 Apr 24

2. "Dataset of human EDEM2 melanoma cells proteomics, affinity proteomics and deglycoproteomics" Gabriela N. Chirițoiu, Marioara Chirițoiu, Cristian V.A. Munteanu, Data in Brief Volume, 2021, doi: 10.1016/j.dib.2021.107471

Conferences

2020

1. Oral presentation: "Non-conventional proteins involved in interleukin-1β secretion from primary macrophages"

Nathalie Brouwers (1), Gheorghița Isvoranu (2), Ștefana M. Petrescu (3), Vivek Malhotra (1), Marioara Chiriţoiu (1,3)

1. Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology,

Barcelona, Spain

2. "Victor Babeș" National Institute of Pathology, Bucharest, Romania
3. Institute of Biochemistry of the Romanian Academy, Bucharest, Romania

A 4-a Conferință a Asociației Române de Imuno-Dermatologie, A 49-a Conferință a Societății de Imunologie din România

2. Oral presentation: "Caracteristici fenotipice ale celulelor NK induse de prezența celulelor tumorale" Gheorghița Isvoranu (1), Mihaela Surcel (1), Adriana Narcisa Munteanu (1), Ioana-Ruxandra Pîrvu (1), Monica Teodora Neagu (1)

1. "Victor Babeș" National Institute of Pathology, Bucharest, Romania;
2. University of Bucharest, Faculty of Biology, Bucharest, Romania

A 4-a Conferință a Asociației Române de Imuno-Dermatologie, A 49-a Conferință a Societății de Imunologie din România

2021:

1. Oral presentation: "Proteine neconvenționale implicate în secreţia interleukinei-1β din macrofage primare"

Nathalie Brouwers (1), Gheorghița Isvoranu (2), Ștefana M. Petrescu (3), Vivek Malhotra (1), Marioara Chiriţoiu (1,3)

1. Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology,

Barcelona, Spain

2. "Victor Babeș" National Institute of Pathology, Bucharest, Romania
3. Institute of Biochemistry of the Romanian Academy, Bucharest, Romania

Conferința Cercetării Științifice din Academia Română (CCSAR-2021)

2. Poster: "Phenotypic and functional characterisation of NK cells in metastatic melanoma"

Gheorghita Isvoranu (1), Mihaela Surcel (1), Adriana Narcisa Munteanu (1,2), Carolina Constantin (1,3), Emilia Manole (1,3), Marioara Chiritoiu-Butnaru (4), Monica Teodora Neagu (1,2,3)

1 „Victor Babeș” National Institute of Pathology, Bucharest, Romania
2. Doctoral School of Biology, Faculty of Biology, University of Bucharest, Bucharest, Romania
3 Colentina Clinical Hospital; Bucharest, Romania
4 Institute of Biochemistry of the Romanian Academy, Bucharest, Romania

2nd International Conference „Cancer Metastasis“

3. Poster: "Natural Killer Cells Immunophenotyping in Metastatic Melanoma"

Gheorghita Isvoranu (1), Mihaela Surcel (1), Adriana Narcisa Munteanu (1,2), Ioana Ruxandra Pirvu (1), Carolina Constantin (1,3), Emilia Manole (1,3), Marioara Chiritoiu-Butnaru (4), Monica Teodora Neagu (1,2,3)

1 „Victor Babeș” National Institute of Pathology, Bucharest, Romania
2. Doctoral School of Biology, Faculty of Biology, University of Bucharest, Bucharest, Romania
3 Colentina Clinical Hospital; Bucharest, Romania
4 Institute of Biochemistry of the Romanian Academy, Bucharest, Romania

International Pathology Conference of „Victor Babeș” Institute, Romania, 04-06.11.2021, eveniment online.

4. Poster: "Phenotypic and functional characterization of NK cells in metastatic melanoma" Gheorghita Isvoranu, Mihaela Surcel, Adriana-Narcisa Munteanu, Carolina Constantin, Emilia Manole, Marioara Chiritoiu-Butnaru, Monica-Teodora Neagu.

1 „Victor Babeș” National Institute of Pathology, Bucharest, Romania
2. Doctoral School of Biology, Faculty of Biology, University of Bucharest, Bucharest, Romania
3 Colentina Clinical Hospital; Bucharest, Romania
4 Institute of Biochemistry of the Romanian Academy, Bucharest, Romania

2nd International Conference „Cancer Metastasis”, Austria, 13-17.12.2021, eveniment online.

2022

1. Poster: "Phenotypic changes in tumor-primed murine NK cells” Gheorghita Isvoranu1, Carolina Constantin1, Mihaela Surcel1, Adina-Narcisa Munteanu1, Marioara Chiritoiu-Butnaru2, Monica Neagu1,

1 „Victor Babeș” National Institute of Pathology, Bucharest, Romania
2. Institute of Biochemistry of the Romanian Academy, Bucharest, Romania

8th Symposium on Advances in Cancer Immunology and Immunotherapy, 1-3 Decembrie 2022, Athens, Greece

2. Oral presentation: "CRISPR-mediated generation of a reporter cell line to study (neuro)inflammation” Gabriela Chiritoiu1, Simona Ghenea1, Gheorghita Isvoranu2, Marioara Chiritoiu-Butnaru1

1. Institute of Biochemistry of the Romanian Academy, Bucharest, Romania
2. „Victor Babeș” National Institute of Pathology, Bucharest, Romania

Congresul Universității de Medicină și Farmacie “Carol Davila” din București, 10-12 Noiembrie 2022, Bucuresti, Romania

3. Oral presentation: "Generation of a Receptor Cell Line Suitable for High Throughput Screening of Molecules with Anti-Inflammatory Capacity" - Gabriela Chiritoiu1, Simona Ghenea1, Cristian V.A. Munteanu1, Cosmin Trif1, Costin Ioan Popescu1, Laurentiu Spiridon1, Mihaela Uta1, Livia Sima1, Sorin Tunaru1, Stefana M. Petrescu1, Gina Simion2, Gheorghita Isvoranu2, Marioara Chiriţoiu-Butnaru1

1. Institute of Biochemistry of the Romanian Academy, Bucharest, Romania
2. „Victor Babeș” National Institute of Pathology, Bucharest, Romania

EU-OPENSCREEN DRIVE Workshop 2021- “Medicinal chemistry in drug discovery, new therapeutical approaches”H2020 - INFRADEV-03-2018-2019 Ensuring long-term sustainability of excellence in chemical biology within Europe and beyond- 19 Octombrie 2022, Timisoara, Romania

4. Poster: “Generation of a reporter cell line to study (neuro)inflammation” Gabriela Chiritoiu1, Simona Ghenea1, Gheorghita Isvoranu2, Marioara Chiritoiu-Butnaru1

1. Institute of Biochemistry of the Romanian Academy, Bucharest, Romania

2. "Victor Babeș" National Institute of Pathology, Bucharest, Romania

Cell Symposia: The Biology of Neuropsychiatric Disorders, 15-17 Mai 2022, Sitges, Spain